Case Study Neuro Device

Mitochondrial Markers in Human Dopaminergic iPSCs Neurons

A Parkinson model with human neurons:
• Increased number of neurites
• Easy quantification of axonal transport
• More results with 10x fewer cells

Case Study Neuro Device

Clear isolated axons from human iPSCs-derived neurons

Ananda Devices enabled to obtain over 1 mm long axons in less than 7 days.

Case Study Neuro Device

Easily identify neurites and track their growth

Clear identification and analysis of neurite growth in hippocampal cultures for 15 days in vitro
• Healthy cultures for more than 2 weeks in vitro
• Efficient tracking of microtubule dynamics
• Clear identification of neurites and their structures

Case Study Migration Device Small

Microfludic devices to study cancer adhesion and invasion

Cancer cells explore the environment sending long membrane protrusions (arrowhead) and are capable of squeezing themselves trying to invade channels much smaller than their own size (arrow).

Case Study Neuro Device

Axotomy performed on parallel axons using Ananda’s microfluidic devices

One step regeneration test to easily identify new drugs that modulate axonal growth
• Isolation of soma and axonal compartments
• Axons presented in parallel enabled for optimal axotomy
• Easy tracking of axonal growth post-axotomy.

Case Study Neuro Device

Extension of axons isolated using Ananda´s Neuro Device

Neurons grown on ANANDA'S microfluidic chambers connected using atomic force microscopy. Magdesian and al.J.Neuroscience 2016.

Case Study Migration Device Medium

Human microglial cell migration

• Clear identification of migration direction
• Easy quantification of migration

Case Study Neuro Device

Neuronal Degeneration

Single hippocampal axons were extended in ANANDA's microfluidic devices, enabling single axonal compression using AFM and subnano forces.

Case Study Neuro Device

Simplify the observation of synapse formation

Dr. Annalisa Lucido (McGill University, Canada) while studying synapse formation.
With Ananda microfluidic devices, Dr. Lucido obtained healthy neuronal cultures for over 3 weeks in vitro...

Case Study Migration Device Large

Microdevices to study parasite motility and migration

Protozoa parasites (green) migrate through thin channels attracted by specific proteins present in another compartment. The number of parasites in the channels increase with time.

Case Study Neuro Device

Studying healthy neuronal cultures for 4 weeks in vitro

Dr. Margaret Magdesian (McGill University, Canada) was studying synapse formation and measuring neuronal electrical activity.

Case Study Neuro Device

Easy analysis of axonal transport

Dr. Mohamad Khazaei (University of Toronto, Canada) required easy identification of axons with uniform dimensions in order to efficiently analyze axonal transport.

Case Study Co-Culture Device

Connection of two isolated neuronal populations

Pipette micromanipulation guides the extension (> 250 µm) of the new filament from population one over the gap and the formation of a connection with the neuronal population two.

Case Study Neuro Device

Study axonal degeneration of 120 parallel axons

Dr. Margaret Magdesian (Montreal Neurological Institute at McGill University, Canada) while studying axonal degeneration

“With Ananda microfluidic devices, we were able to simultaneously injure 120 parallel axons and follow the regeneration process in one dish..."

Other

Microfluidic devices to study cell adhesion and differentiation

Myoblasts (C2C12 line) adhesion and differentiation on netrin-1 microcontact printed stripes (red).

Case Study Neuro Device

Easily study myelination

Dr. Dalinda Liazoghli, McGill University, while studying myelination of DRG axons.

With Ananda microfluidic devices, Dr. Dalinda Liazoghli was able to grow DRG neurons for several weeks...

Publications

Ananda offers a new approach to quantify & analyze data at the single-cell level

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