NeuroHTS™

One platform. Multiple applications. Human-relevant neuronal research with high-throughput and reproducibility.

Next Generation Neuroscience Discovery Platform

NeuroHTS™ is a high-throughput microfluidic platform designed to organize neuronal cultures in precisely structured networks, improving reproducibility and physiological relevance compared to conventional in vitro models.

Built on a standard 384-well microplate format, each NeuroHTS™ plate contains 28 independent microfluidic units, enabling parallel testing of multiple experimental conditions while remaining fully compatible with standard plate readers, microscopes, and automated workflows. The platform supports all primary neurons as well as iPSC-derived neuronal lines, allowing researchers to clearly visualize and quantify morphological and functional changes induced by compounds, disease models, peptides, or genetic perturbations.

Unlike traditional neuronal cultures that form entangled and irreproducible networks, NeuroHTS™ guides neurons into structured, reproducible architectures that more closely reflect in vivo organization. This controlled organization enables scalable, high-content analysis with single-cell resolution.

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NeuroHTS™ 384-well microplate thumbnail view of neuronal cultures

Key Capabilities1

Reproducible organization of neuronal networks with single-cell precision

Applications

NeuroHTS™ supports a wide range of neuroscience applications, enabling high-throughput, human-relevant evaluation of neuronal structure, function, and response.

Disease Modeling & Pathophysiology

Model neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS, as well as peripheral neuropathies using patient-derived iPSC neuronal systems.

Drug Discovery & Safety

High-throughput screening for drug efficacy, neurotoxicity profiling, and evaluation of chemotherapy-induced neuronal toxicity.

Neuronal Injury & Regeneration

Study spinal cord injury, axotomy-induced damage, and axonal degeneration and regeneration mechanisms for regenerative medicine research.

Advanced Functional & Cellular Readouts

Axonal transport compatible combined with mitochondrial profiling and transport analysis for comprehensive neuronal function assessment.

Representative Cases

Illustrative Neurodegenerative Disease Modeling examples demonstrating the capabilities of NeuroHTS™. Detailed datasets and study designs are available upon request.

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NeuroHTS™ enables high-content, single-cell analysis of neurons derived from healthy and Alzheimer's donors, revealing disease-associated changes in neuronal morphology, network organization, and function. Multiparametric profiling allows quantification of reductions in cell number, axonal material, branching complexity, and network integrity, while supporting long-term cultures (>40 days) for longitudinal studies and downstream validation.

What this demonstrates

Disease-relevant neuronal phenotypes at single-cell resolution
Long-term culture stability for progressive neurodegeneration studies
Compatibility with complementary assays (e.g., electrophysiology, secretion assays)